Lipid core-encapsulated cannabidiol causes anxiolytic- and panicolytic-like effects on defensive behavior elicited in mice by Bothrops jararaca lancehead pit vipers
B.M. de Paula Rodrigues1, H.F. Martins Alves1, R.C. Balvedi1, P.M. Hernandes1, M.M. de Barros Tarozzo1, S.R. Ferrarini2, N.C. Coimbra1
1University of São Paulo, FMRP-USP Department of Pharmacology, Ribeirão Preto, Brazil, 2Federal University of Mato Grosso, UFMT Department of Chemistry, Sinop, Brazil
Background: The burgeoning interest in cannabinoid-based therapies for mental disorders motivates research into their efficacy.
Aims & Objectives: This study aimed to investigate the acute effects of nanoencapsulated cannabidiol (CBD) on panic attack-like defensive responses elicited in mice by the venomous snake Bothrops jararaca in polygonal arenas validated as a panic attack experimental model.
Method: Mice were habituated in the enriched polygonal arena during three days and treated with either CBD or nanostructured CBD at different doses before snake confrontation.
Results: Mice displayed antipredatory behaviours when confronted by snakes compared to a non-threatening stimulus, emphasising the validity of the panic model. Both non-encapsulated and nanoencapsulated CBD, in this latter formulation particularly at lower doses, attenuated panic-like responses, including defensive attention, flat back approach, and escape behaviours to safe places.
Discussion & Conclusions: These findings suggest that nanoencapsulated CBD holds promise as an effective treatment for anxiety disorders, potentially mitigating adverse effects associated with cannabinoid therapy.
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